This is the last WAVE of the summer. It has been a pleasure
meeting all of you. We hope everyone of you had an enjoyable and educational
summer. We wish you the very best in your future endeavors!
Here's where SFP students and others can announce events
or opportunities. These entries should be succinct and must include a contact
name and e-mail address. Entries must be received by 8AM Friday morning
prior to the weekly WAVE posting.
Contact: Jason Casey
Dr. Paul Patterson - Student Research Opportunities
Mentors: Ali Khoshnan & Paul Patterson, Biology
Division
Highly motivated students are needed for research on the
role of IKKg in amyloidogenesis. IKKg is a regulatory component of
the Ik-B kinase complex and modulates the NF-kB signaling pathway. Previous
work in this laboratory has shown that IKKg binds to mutant huntingtin
protein (Htt, which causes Huntington's disease, HD) and promotes its oligomerization
and toxicity (Khoshnan et al., 2004). Our recent data show that IKKg
also interacts with amyloid-precursor protein (APP, which when mutated
causes Alzheimer's disease, AD). We hypothesize that IKKg regulates
proteolysis of APP and production of the amyloidogenic peptide Ab, which
is the active factor in AD. Students will undertake biochemical
and molecular analyses of IKKg/APP interaction and examine how this interaction
regulates production of Ab oligomers and neurodegeneration.
Another project involves exploring the neuroprotective function
of pleiotrophin (PTN) in HD. PTN is a neurite outgrowth promoting factor
that is expressed in the brain and its levels are elevated by injury. Our
work shows that PTN levels are also induced by mutant Htt. Moreover, exogenous
PTN reduces the aggregation and toxicity of mutant Htt. Students will investigate
the mechanism of PTN-induced neuroprotection in HD cellular and animal
models.
References:
Khoshnan A, Ko J, Watkin EE, Paige LA, Reinhart PH and Patterson PH (2004)
Activation of the Ik-B kinase complex and NF-kB contributes to mutant
huntingtin neurotoxicity. J Neurosci 24:7999-8008.
Selkoe, DJ and Schenk, D (2003) Alzheimer’s disease: Molecular understanding
predicts amyloid-based therapeutics. Annu Rev Pharmacol Toxicol 43:
545-584.
Zoghbi, HY and Orr, HT (2000) Glutamine repeats and neurodegeneration. Annu
Rev Neurosci 23: 217-248.
Contact: Dr. Paul Patterson
Visual Experiment in the Broad Center
We are looking for subjects to participate in an experiment
in which you will be asked to look at pictures on a computer screen and
perform a task on them. This simple experiment will take place in Broad
and consists of two sessions, one hour per day, on consecutive days.
Compensation is $15/hour. Please show up on time!
Please contact Csilla by e-mail, csilla@caltech.edu, to schedule
two sessions.
If your session is between 8 am - 5 pm, please find me in Broad 63
(basement) at your scheduled time. Otherwise, I will meet you at the Broad
entrance that is facing Broad Cafe to let you into the building.
Available times and dates (please choose at least two so
that we can setup sessions on consecutive days):
Sunday, August 12 - 7:15 - 8:15 pm; 8:30 - 9:30 pm
Monday, August 13 - 10:30 - 11:30 am; 7 - 8 pm; 8:15 - 9:15
pm, 9:30 - 10:30 pm
Tuesday, August 14 - 8 - 9 am; 9:15 - 10:15 am; 10:30 - 11:30
am; 5:15
- 6:15 pm; 6:30 - 7:30 pm; 7:45 - 8:45 pm; 9 - 10 pm
Wednesday, August 15 - 11:15 - 12:15 pm; 12:30 - 1:30 pm;
1:45 - 2:45 pm; 3 - 4 pm; 4:15 - 5:15 pm; 5:30 - 6:30 pm; 6:45 - 7:45 pm;
8 - 9 pm
Saturday, August 18 - 8 - 9 am; 9:15 - 10:15 am; 10:30 -
11:30 am;
11:45 - 12:45 pm; 1 - 2 pm; 2:15 - 3:15 pm; 3:30 - 4:30 pm; 4:45 -
5:45 pm; 6 - 7 pm
Sunday, August 19 - 8 - 9 am; 9:15 - 10:15 am; 10:30 - 11:30
am; 11:45
- 12:45 pm; 1 - 2 pm; 2:15 - 3:15 pm; 3:30 - 4:30 pm; 4:45 - 5:45 pm;
6 - 7 pm
If none of these work for you but you are still interested,
please ask for other times that would be more convenient for you.
Contact: Csilla Felsen
A Midsummer Night's Dance
Come join us on this lovely summer evening for an enchanted
night of dancing!
Featuring: Swing, Tango, Latin & Ballroom music, mixers,
refreshments, and lots of DANCING!
When: Saturday, August 11, from 9:00 pm until the music stops!
Where: Winnett Lounge (2nd floor)
Mini-lesson: TBA at 8:30pm
Cost: Free for Caltech/JPL affiliates (with ID);
$5 for non-Caltech.
Contact: Csilla Felsen
RECOMB Comparative Genomics workshop at UCSD in September
CALL FOR POSTERS
Fifth Annual RECOMB Satellite Workshop on Comparative Genomics
(RECOMB-CG'07)
September 16-18, 2007
Center for Algorithmic and Systems Biology
University of California, San Diego
La Jolla, California, U.S.A.
http://casb.ucsd.edu/recombcg07
Poster submission deadline August 17, 2007
Notification of poster acceptance August 24, 2007
Topics of interest include, but are not limited to
* Algorithms in comparative genomics
* Comparative study of orthologous genes
* Gene finding using multiple genomes
* Sequence homology
* Genome rearrangements
* Measures of evolutionary distance
* Whole genome phylogeny reconstruction
* Sequence assembly using sequence comparison
* Multiple genome alignment
* Gene and genome duplication
* Gene tree reconciliation
* Identification of conserved and fast evolving sequences
Please visit http://casb.ucsd.edu/recombcg07 for
program
information, including keynote speakers and contributed talks;
organization and program committees; and registration information.
Register by August 17 for early rates.
Contact: http://casb.ucsd.edu/recombcg07
Journal of Young Investigators: Call for research article submissions
The Journal of Young Investigators is an online undergraduate
peer-reviewed science journal that accepts manuscript submissions from
undergraduate science researchers. It could be a great place to publish
your summer research!
See www.jyi.org for submission
instructions and forms and guidelines for writing a publishable scientific
paper.
Contact: Melinda Morang
Journal of Young Investigators: Join the staff!
The Journal of Young Investigators is an online undergraduate
peer-reviewed science journal that accepts manuscript submissions from
undergraduate science researchers. JYI is run completely by undergraduates
and is currently accepting applications for various positions.
See http://www.jyi.org/participate.php for
the available positions and for application instructions.
Contact: Melinda Morang
Leaving international student is selling Plymouth Grand Voyager SE,
$2500
Second owner, 1997, 215 000 mile, V6 3.3L, air condition,
airbags, cassette radio,....; Kelley Blue Book: Private Party Value:
Good: $3000 perfect driving and good optical condition (except for dent
and scratches on left sliding door and fuel door), garage kept and well
serviced; smog test for next owner passed, oil changed, brakes checked.
Contact: Lothar Ratschbacher
Dance Events
Beginner Argentine Tango: Introduction to Milonga ________________________________________________________________________
Instructor: With professional instructor Vladimir Estrin.
When: 8 Sundays, starting July 22 to September 16, 8:00-9:30 pm.
NOTE: No class on August 26 due to a workshop.
Where: In Dabney Hall
Cost: FREE for Caltech Undergrad & Grad students (with ID); $5/class
or $35/series for Caltech affiliates & other university students* (with
ID); $8/class or $56/series regular.
*Discounts apply for full-time students from any college/university/institution.
Please bring a current student ID.
** Series price paid in whole on the first day of class.
About: Milonga, along with vals and tango, make up the triad
of music and
dance forms of Argentine Tango. Set to a lively 2/4 tempo music, milonga
uses the same basic elements as tango, though the movement is more accented
and upbeat. It is rather a kind of rhythmic walking without the complicated
figures of tango.
Notes: NO dance experience or partner necessary. Tango is
danced in close position with figures that require a lot of pivoting on
the balls of your feet. As such, it is ideal for beginners to wear close-toed
shoes with smooth bottoms -- suede or leather is ideal, hard rubber is
ok. Most ladies wear heels -- if you do so, make sure to choose a pair
with straps so that the heel is NOT loose, this will aid in your pivots.
Contact: Csilla Felsen
Carpe Diem
Want to find out what's going on? Subscribe to Carpediem.
Send a blank email to carpediem07-join@caltech.edu to
get started. Carpediem is an email list for spontaneous student-organized
happenings. Using Carpediem, you can put together a pickup soccer game
or a trip to the beach with other SFP students or maybe find out about
an awesome concert downtown.
Shopping/restaurant runs, free leftover food, museum trips -- the possibilities
are endless. To join carpediem, send a blank email to carpediem07-join@caltech.edu.
Send an email to the list when you want to do something or just keep an
eye out for things that excite you.
There's no commitment and nothing to lose. It'll be fun.
Questions? Email timothys@caltech.edu.
La Parilla at Broad Cafe
La Parilla at Broad offers authentic Mexican dishes. Menu items range
from Tamales and Enchiladas, tacos to burritos to tortas served with
grilled carne asada, carnitas or chicken. A fresh salsa bar is available
to spice up your meal. Grilled hamburgers and chicken sandwiches are
also available.
La Parilla is the only campus dining
area that sells beer and wine (alcohol may not be purchased with dining
card). La Parilla offers half off appetizers to all customers during
Happy Hour; Monday-Friday from 4-6 pm. Appetizers include nachos, taquitos,
jalapeno poppers, buffalo wings and much more.
For more information, including
a complete menu, please visit dining.caltech.edu or call 626 395 6174.
Christian Fellowship
The Caltech Christian Fellowship welcomes you to Caltech for Summer 2007!
The Caltech Christian Fellowship (CCF) is a multi-denominational student-run
group that welcomes everyone to join the Body of Christ on campus. We would
like to invite you to participate in our activities this summer!
Summer Prayer- A time of fellowship and prayer for one and
other. Every Monday at 8:30 PM in Beckman Institute (BI) Courtyard
Summer Study- Though summer dining options may be limited, you can still
be fed by the Word of God! Join us for small group / Bible study every
Wednesday night at 8:00 PM in Avery Library.
Tensing – Singing at 10PM, hence ten-sing! Praise and worship in
the cool summer nights every Thursday at 10 PM on Millikan Bridge. Guitarist
provided.
Contact: Brandon Hensley
